About The Conference

Understanding why and how people carrying pathogenic variants remain free of disease and thus trying to unravel underlying mechanisms of endogenous disease protection of hereditary movement disorders is the overarching theme of the ProtectMove Research Unit. This DFG-funded program project coordinated in Luebeck, Germany, spans the fields of geneticists, molecular and cellular biology, movement disorders, epidemiology and statistics.

The goal of the REDUCED PENETRANCE CONFERENCE is to bring together outstanding international scientists to share data, research ideas and perspectives and to set up new collaborative efforts related to reduced penetrance and, more generally speaking, resilience.

Research Breaktroughs

Penetrance of Movement Disorders Gene Mutations in 20.000 patients and controls.

Large-scale GWAS in dystonia.

Genetic modifiers influencing penetrance and x-linked dystonia-parkinsonism.

Networking Opportunities

Meet the professor.

Networking lunch.

Poster presentations.

Gain New Insights

Mechanisms underlying reduced penetrance.

Exploring the role of the 3D-Genome in penetrance.

Ethics of recall by genotype.

Meet Our Speakers
  • Jan Aasly
    Jan Aasly
    Norwegian University of Science and Technology, Norway
    Talk: "Reduced penetrance in Norwegian LRRK2 mutation carriers".
  • Daniela Berg
    Daniela Berg
    University Hospital Schleswig-Holstein
    Talk: "Reduced penetrance in light of prodromal signs and symptoms of Parkinson’s disease".
  • Matthew Farrer
    Matthew Farrer
    University of British Columbia, Canada
    Talk: "Parkinson’s, penetrance and the development of precision medicine”.
  • Andreas Hermann
    Andreas Hermann
    German Center for Neurodegenerative Diseases, Germany
    Talk: "Vulnerability vs. reduced penetrance: the selectivity of neurodegeneration".
  • Peter-Robin-Hiesinger
    Peter Robin Hiesinger
    Free University of Berlin, Germany
    Talk: "The role of intrinsically noisy brain development for reduced penetrance in Drosophila”.
  • Frank-Kaiser
    Frank Kaiser
    University of Lübeck
    Conference Co-Chair
  • Christine Klein
    Christine Klein
    University of Lübeck
    Conference Co-Chair
  • Dimitri Krainc
    Dimitri Krainc
    Feinberg School of Medicine - Northwestern University, USA,
    Talk: “Mechanistic insights into GBA1-associated Parkinson’s disease: Reduced penetrance or risk factor?”.
  • Alastair Noyce
    Alastair Noyce
    University of London, UK
    Talk: "Using Mendelian randomisation to explore causal risk factors and their penetrance for Parkinson’s disease”.
  • Constantin Polychronakos
    McGill University, Canada
    Talk: "Penetrance as a Complex Trait”.
  • Patrik Verstreken
    Patrik Verstreken
    VIB-KU Leuven Center for Brain & Disease Research, Belgium
    Talk: "Sleep defects in Parkinson’s disease occur with high penetrance”.
  • Richard Youle
    Richard Youle
    National Institutes of Health, USA
    Talk: "Penetrance of inflammation with Parkin and PINK1 mutant gene dosage”.
Monday, December 10th, 2018

Arrival Day

Schedule

3:00 – 4:00 pm Registration
4:00 – 4:45 pm Christine Klein and Frank Kaiser – Welcome and Introduction into the DFG Research Unit on Reduced Penetrance of Hereditary Movement Disorders
4:45 – 5:30 pm Introduction Lecture II: Constantin Polychronakos – Penetrance as a Complex Trait
5:30 – 6:15 pm Daniela Berg – Reduced penetrance in light of prodromal signs and symptoms of Parkinson’s disease
6:15 – 6:30 pm Closing remarks by Christine Klein and Frank Kaiser
   
   
   
   
Tuesday, December 11th, 2018

Morning Session

Schedule

9:00 – 9:30 am Welcome and update by Christine Klein and Frank Kaiser
9:30 – 10:15 am Introduction Lecture I: Matt Farrer – Parkinson’s, penetrance and the development of precision medicine
10:15 – 11:00 am Introduction Lecture II: Dimitri Krainc – Mechanistic insights into GBA1-associated Parkinson’s disease: Reduced penetrance or risk factor?
11:00 – 11:30 am Coffee break
11:30 – 12:15 am Richard Youle – Penetrance of inflammation with Parkin and PINK1 mutant gene dosage
12:15 – 1:00 pm Jan Aasly – Reduced penetrance in Norwegian LRRK2 mutation carriers
1:00 – 2:30 pm Lunch
Tuesday, December 11th, 2018

Afternoon Session

Schedule

2:30 – 3:15 pm Robert Hiesinger – The role of intrinsically noisy brain development for reduced penetrance in Drosophila
3:15 – 4:00 pm Patrik Verstreken – Sleep defects in Parkinson’s disease occur with high penetrance
4:30 – 5:00 pm Coffee break
5:00 – 5:45 pm Andreas Herrmann – Vulnerability vs. reduced penetrance: the selectivity of neurodegeneration
5:45 – 6:30 pm Alastair Noyce – Using Mendelian randomization to explore causal risk factors and their penetrance for Parkinson’s disease
6:30 – 6:45 pm Closing remarks by Christine Klein and Frank Kaiser
7:30 pm Dinner at „The Newport“
www.the-newport.de
RESERVATIONS

Katja Herrmann-Malzahn
Institute of Neurogenetics
University of Lübeck
+49 451-3101-7491

katja.herrmannmalzahn@uni-luebeck.de

ORGANIZATION

Dr. Michaela Trilck
Institute of Neurogenetics
University of Lübeck
+49 451-3101-8203

michaela.trilck@neuro.uni-luebeck.de

Conference Will Start in

146Days
7Hours
8Mins
9Secs

Conference Fee

Registration fees: 100,00 EUR

Registration fees (dinner included): 140,00 EUR

Registration fees for students: 50,00 EUR

Registration fees for students (dinner included): 75,00 EUR

 

Payment

Registration fees shall be paid in the following account by bank transfer:

Universitätsklinikum Schleswig-Holstein
Deutsche Bank Lübeck
IBAN: DE30 2307 0710 0872 0815 00
SWIFT/BIC: DEUT DE HH 222
Payment reference: F275090 „reduced penetrance Conference 2018“

Venue

Radisson Blu Senator Hotel, Willy-Brandt-Allee 6, 23554 Lübeck, Germany

Conference room “Lübeck 1 + 2”

Funding & Partners